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Definition


Zollinger-Ellison Syndrome Definition
Common names:
  • Gastrin Hypersecretion
  • Gastrinoma
  • Hypersecretion of Gastrin
  • Zollinger-Ellison Syndrome
What is Zollinger-Ellison syndrome?
A person with Zollinger-Ellison syndrome has a tumor in the stomach or pancreas that stimulates the stomach to produce more acid than usual. The increased acid can destroy the cells that line the stomach and intestine. Zollinger-Ellison syndrome can lead to peptic ulcer disease and malabsorption. Images

What are the symptoms of Zollinger-Ellison syndrome?
Symptoms of Zollinger-Ellison syndrome include upper abdominal pain. The pain may be worse on an empty stomach, and may be relieved with antacids. Additional symptoms of Zollinger-Ellison syndrome include heartburn, hiccups, indigestion, nausea, vomiting, and weight loss. Images

How does the doctor treat Zollinger-Ellison syndrome?
Treatment for Zollinger-Ellison syndrome includes medications that block acid production in the stomach, or surgery. Severe Zollinger-Ellison syndrome may require chemotherapy.

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Last Updated: Feb 24, 2009  References
Authors: Stephen J. Schueler, MDJohn H. Beckett, MDD. Scott Gettings, MD
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