Stephen J. Schueler, M.D.

Yersinia Pestis Antibiotic Prophylaxis

People who are exposed to an individual with pneumonic plague require antibiotics for seven days, in order to prevent the disease.


  • Prophylactic antibiotics should be given to those who have been exposed to rodent fleas during a plague outbreak.
  • Prophylactic antibiotic therapy is recommended for persons who have handled an animal that is infected with the plague.
  • Prophylactic antibiotic therapy is recommended for persons who have had close exposure to a person or an animal with plague pneumonia.
  • Antibiotics for prophylaxis against plague:

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Last Updated: Dec 2, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Yersinia Pestis References
  1. Cobbs CG, Chansolme DH. Plague. Dermatol Clin. 2004 Jul;22(3):303-12, vi. [15207311]
  2. Duncan CJ, Scott S. What caused the Black Death? Postgrad Med J. 2005 May;81(955):315-20. [15879045]
  3. Kool JL. Risk of person-to-person transmission of pneumonic plague. Clin Infect Dis. 2005 Apr 15;40(8):1166-72. [15791518]
  4. Lazarus AA, Decker CF. Plague. Respir Care Clin N Am. 2004 Mar;10(1):83-98. [15062229]
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