Wilms Tumor Underlying Cause
The cause of Wilm's tumor is unknown, but genetics may play a role in determining risk.
Genes control the functions inside a cell. Special genes control how cells divide and grow. Cancer occurs when the damaged genes stimulate the cell to multiply out of control. The exact cause for this damage is unknown.
Continue to Wilms Tumor Anatomy
- Blakely ML, Shamberger RC, et al; National Wilms' Tumor Study Group. Outcome of children with cystic partially differentiated nephroblastoma treated with or without chemotherapy. J Pediatr Surg. 2003 Jun;38(6):897-900. 
- Kremens B, Gruhn B, Klingebiel T, et al. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. Bone Marrow Transplant. 2002 Dec;30(12):893-8. 
- McLorie GA. Wilms' tumor (nephroblastoma). Curr Opin Urol. 2001 Nov;11(6):567-70. 
- Pritchard-Jones K, Kelsey A, et al; United Kingdom Children's Cancer Study Group; Wilm's Tumor Working Group. Older age is an adverse prognostic factor in stage I, favorable histology Wilms' tumor treated with vincristine monochemotherapy: a study by the United Kingdom Children's Cancer Study Group, Wilm's Tumor Working Group. J Clin Oncol. 2003 Sep 1;21(17):3269-75.