Stephen J. Schueler, M.D.

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Wegener's Granulomatosis Overview

What is Wegener's granulomatosis?
A person with Wegener's granulomatosis has inflammation and swelling of the blood vessels in the lungs, ears, nose, throat, and kidneys. Wegener's granulomatosis results from an abnormal immune system, which normally fights infection. The immune system mistakenly attacks normal blood vessels, which causes inflammation and swelling of the blood vessels. The cause of the abnormal immune system in Wegener's granulomatosis is unknown. Wegener's granulomatosis is a rare disease that may also spread to the eyes, skin and joints. About 1 out of 200,000 people in the US develop Wegener's granulomatosis each year.

What are the symptoms of Wegener's granulomatosis?
Symptoms of Wegener's granulomatosis may include bloody urine, cough, difficulty breathing, eye redness, facial pain, fatigue, fever, sinus congestion, rash, loss of appetite, and unintentional weight loss.

How does the doctor treat Wegener's granulomatosis?
Treatment of Wegener's granulomatosis includes oral corticosteroids, and other medications that help reduce inflammation and swelling.

Continue to Wegener's Granulomatosis Incidence

Last Updated: Aug 31, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Wegener's Granulomatosis References
  1. Albert D, Clarkin C, Komoroski J, Brensinger CM, Berlin JA. Wegener's granulomatosis: Possible role of environmental agents in its pathogenesis. Arthritis Rheum. 2004 Aug 15;51(4):656-64. [15334441]
  2. Lamprecht P, Gross WL. Wegener's granulomatosis. Herz. 2004 Feb;29(1):47-56. [14968341]
  3. Langford CA. Wegener's granulomatosis: current and upcoming therapies. Arthritis Res Ther. 2003;5(4):180-91. [12823849]
  4. Nishiike S, Kato T, Nagai M, Konishi M, Sakata Y. Management and follow-up of localized Wegener's granulomatosis: a review of five cases. Acta Otolaryngol. 2004 Nov;124(9):1103-8. [15513558]
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