Stephen J. Schueler, M.D.

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Von Willebrand's Disease Underlying Cause

Von Willebrand's disease is caused by a gene that results in an inadequate production of von Willebrand's factor in the bloodstream. The Von Willebrand factor is necessary for platelets to form a blood clot.

Normal Blood Coagulation
Normal blood coagulation requires the complex interaction of as many as 20 different plasma proteins. Many of these factors are manufactured in the liver and are regulated by the activities of enzymes and other cofactors.

Continue to Von Willebrand's Disease Anatomy

Last Updated: Sep 5, 2008 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Von Willebrand's Disease References
  1. Gupta PK, Kannan M, Saxena R. Carrier detection in severe von Willebrand's disease. Ann Hematol. 2004 Oct;83(10):625-7. [15316757]
  2. Ingerslev J, Hvitfeldt Poulsen L, Sorensen B. Current treatment of von Willebrand's disease. Hamostaseologie. 2004 Feb;24(1):56-64. [15029274]
  3. Kujovich JL. von Willebrand's disease and menorrhagia: prevalence, diagnosis, and management. Am J Hematol. 2005 Jul;79(3):220-8. [1598123]
  4. Schlammadinger A, Boda Z. Laboratory screening and diagnosis of von Willebrand's disease. Clin Lab. 2002;48(7-8):385-93. [12146572]
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