In infants, about 50% of small ventricular septal defects close without treatment: the hole in the septum closes over time.

Treatment for a ventricular septal defect may include:

• Surgery for ventricular septal defect:
• The opening in the ventricular septum is closed
• Prophylactic antibiotics for ventricular septal defect:
• Treatment with antibiotics before dental procedures and surgery
• Necessary to prevent bacterial endocarditis