Stephen J. Schueler, M.D.

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Ulcer Stomach Drugs

Treatment for peptic ulcer disease usually requires killing the Helicobacter pylori bacteria in the stomach. This is accomplished by taking a combination of antibiotics and acid-blocking drugs. The antibiotics must be taken for 14 days. The acid-blocking medication is usually taken for at least 4 weeks. Your doctor will determine which of the following combinations is best for you.

One of the following antibiotic combination options:

One of the following acid-blocking medication options:

The most commonly prescribed combination of medication used to treat peptic ulcer disease includes:

If one of the above treatment combinations fails, quadruple drug therapy may be used to treat peptic ulcer disease:

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Last Updated: Dec 22, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Ulcer Stomach References
  1. Bodger K, Daly MJ, Heatley RV. Clinical economics review: Helicobacter pylori-associated peptic ulcer disease. Aliment Pharmacol Ther. 1997 Apr;11(2):273-82. [9146763]
  2. Ford A, Delaney B, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003840. [15495066]
  3. Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis. Am J Gastroenterol. 2004 Sep;99(9):1833-55. [15330927]
  4. Vakil N, Fennerty MB. Direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-oesophageal reflux disease and peptic ulcer disease. Aliment Pharmacol Ther. 2003 Sep 15;18(6):559-68. [12969082]
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