The evaluation of thrombotic thrombocytopenic purpura begins with a history and physical examination.

Physical findings in someone with thrombotic thrombocytopenic purpura may include:

• A rash that looks like tiny bruises
• A rash that looks like broken blood vessels in the skin
• Confusion or unresponsiveness
• Signs of anemia:
• Pallor
• Rapid pulse

The diagnosis of thrombotic thrombocytopenic purpura must be confirmed through testing.

Tests that may be used to evaluate thrombotic thrombocytopenic purpura may include:

• Bilirubin level
• Bleeding time
• Platelet count
• Coagulation profile
• Complete blood count
• Gum tissue biopsy:
• Kidney biopsy:
• LDH level