The evaluation of thalassemia begins with a medical history and physical examination.

Physical findings in someone with thalassemia may include:

• Deformed bones of thalassemia
• Enlarged liver
• Enlarged spleen
• Pale skin
• Rapid pulse

Tests are necessary to make the diagnosis of thalassemia.

Tests that may be used to evaluate thalassemia include:

• Complete blood count
• Peripheral blood smear
• Hemoglobin electrophoresis