Systemic Sclerosis Underlying Cause
Scleroderma results from an abnormal immune system, which normally fights infection. The immune system mistakenly attacks normal skin tissue, causing inflammation and scarring of the skin. This process can also damage other parts of the body, including the heart, liver, kidneys, intestines, lungs, blood vessels, and joints. The cause of the abnormal immune system in scleroderma is unknown.
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