The evaluation of syphilis begins with a history and physical exam, including a pelvic exam for females.

Physical findings in someone with syphilis may include:

• Chancre:
• Painless skin ulcers on the genitals
• Painless skin ulcers in other locations
• Inguinal lymphadenopathy:
• Swollen glands in the groin
• Rash:
• Located on the trunk, extremities, palms of the hands, and soles of the feet
• Skin lesions:
• Located on the penis or vagina
• Oral lesions:
• Located on the tongue and inside the mouth
• Fever
• Hair loss

Tests are necessary to make the diagnosis of syphilis.

Tests that may be used to evaluate syphilis include:

• VDRL blood test
• Lumbar puncture