Treatment for splenomegaly depends on the underlying cause. Treatment may include antibiotics, medications that suppress the immune system, chemotherapy, or surgery to remove the spleen.
Treatment for splenomegaly may include:
- Antibiotics to treat an underlying infection
- Medications that suppress the immune system:
- Used when a malfunctioning immune system is targeting healthy blood cells for destruction by the spleen
- Used to treat cancer of the blood cells, which are removed by the spleen
- Surgery to remove the spleen
- May be performed when the spleen is severely damaged from an injury
- May be performed when the spleen is removing too many blood cells, causing anemia
Continue to Splenomegaly Complications
- Hilmes MA, Strouse PJ. The pediatric spleen. Semin Ultrasound CT MR. 2007 Feb;28(1):3-11. 
- Kinderknecht JJ. Infectious mononucleosis and the spleen. Curr Sports Med Rep. 2002 Apr;1(2):116-20.