The evaluation of Reiter's syndrome begins with a complete history and physical examination.

Physical findings in someone with Reiter's syndrome include:

• Conjunctivitis:
• Eye redness
• Eye tearing
• Joint swelling
• Red throat
• Rash

Tests are necessary to make the diagnosis of Reiter's syndrome.

Tests that may be used to evaluate Reiter's syndrome include:

• Blood histocompatibility antigens:
• HLA-B27 testing
• Bone x-rays
• May show arthritic changes in affected joints
• Complete blood count
• Urethral cultures for chlamydia and gonorrhea