Two classes of medication that are most commonly used to treat reflux esophagitis include:

• H2 antagonists
• Proton pump inhibitors

H2 antagonists reduce acid production in the stomach. Proton pump inhibitors stop the production of stomach acid. Usually, they are more effective than H2 antagonists.

H2-blocker medications:

• Ranitidine (Zantac)
• Cimetidine (Tagamet)
• Famotidine (Pepcid)
• Nizatidine (Axid)

Proton pump inhibitor medications:

• Omeprazole (Prilosec)
• Pantoprazole (Protonix)
• Esomeprazole (Nexium)
• Lansoprazole (Prevacid)
• Rabeprazole (Aciphex)