Stephen J. Schueler, M.D.

Overview Symptoms Evaluation Treatment specialist Home Care nosebleed using a cane using crutches warning signs Underlying Cause

Prothrombin Deficiency Underlying Cause

Normal blood clotting requires the complex interaction of about 20 different blood proteins. Many of these proteins are manufactured in the liver and are regulated by the activities of enzymes and other cofactors.

Factor 2 deficiency is an inherited illness. Low levels of this clotting factor result in prolonged blood clotting. Factor 2 deficiency can occur in women as well as men.

Additional causes include:

Last Updated: May 29, 2009 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Prothrombin Deficiency References
  1. Girolami A, Scarano L, Saggiorato G, Girolami B, Bertomoro A, Marchiori A. Congenital deficiencies and abnormalities of prothrombin. Blood Coagul Fibrinolysis. 1998 Oct;9(7):557-69. [9863703]
  2. Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32. [12379290]
  3. Peyvandi F, Mannucci PM. Rare coagulation disorders. Thromb Haemost. 1999 Oct;82(4):1207-14. [10544899]
  4. Williams S, Linardic C, Wilson O, Comp P, Gralnick HR. Acquired hypoprothrombinemia: effects of danazol treatment. Am J Hematol. 1996 Dec;53(4):272-6. [894867]
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