Stephen J. Schueler, M.D.

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Prothrombin Deficiency Overview

Another name for Prothrombin Deficiency is Factor 2 Deficiency.

What is factor 2 deficiency?
A person with factor 2 deficiency has a rare, hereditary blood clotting disorder that can result in severe bleeding. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors. Low levels of factor 2 result in prolonged blood clotting.

What are the symptoms of factor 2 deficiency?
Symptoms of factor 2 deficiency include bleeding into the joints, joint swelling, joint pain, bleeding gums, nosebleeds, and easy bruising. Women may experience heavy menstrual periods.

How does the doctor treat factor 2 deficiency?
There is no cure for factor 2 deficiency. Treatment for factor 2 deficiency may include fresh frozen plasma, factor 2 concentrate, and vitamin K. Patients should avoid aspirin, nonsteroidal anti-inflammatory medications, and other medications that can promote bleeding.

Continue to Prothrombin Deficiency Symptoms

Last Updated: Feb 8, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Prothrombin Deficiency References
  1. Girolami A, Scarano L, Saggiorato G, Girolami B, Bertomoro A, Marchiori A. Congenital deficiencies and abnormalities of prothrombin. Blood Coagul Fibrinolysis. 1998 Oct;9(7):557-69. [9863703]
  2. Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32. [12379290]
  3. Peyvandi F, Mannucci PM. Rare coagulation disorders. Thromb Haemost. 1999 Oct;82(4):1207-14. [10544899]
  4. Williams S, Linardic C, Wilson O, Comp P, Gralnick HR. Acquired hypoprothrombinemia: effects of danazol treatment. Am J Hematol. 1996 Dec;53(4):272-6. [894867]
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