Stephen J. Schueler, M.D.

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Progressive Systemic Sclerosis Underlying Cause

Scleroderma results from an abnormal immune system, which normally fights infection. The immune system mistakenly attacks normal skin tissue, causing inflammation and scarring of the skin. This process can also damage other parts of the body, including the heart, liver, kidneys, intestines, lungs, blood vessels, and joints. The cause of the abnormal immune system in scleroderma is unknown.

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Last Updated: Jun 17, 2009 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Progressive Systemic Sclerosis References
  1. Bottoni CR, Reinker KA, Gardner RD, Person DA. Scleroderma in childhood: a 35-year history of cases and review of the literature. J Pediatr Orthop. 2000 Jul-Aug;20(4):442-9. [10912598]
  2. Haustein UF. Systemic sclerosis-scleroderma. Dermatol Online J. 2002 Jun;8(1):3. [12165213]
  3. Zulian F. Scleroderma in children. Pediatr Clin North Am. 2005 Apr;52(2):521-45, vii. [15820378]
  4. Zulian F. Systemic manifestations in localized scleroderma. Curr Rheumatol Rep. 2004 Dec;6(6):417-24. [15527700]
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