The evaluation of polycythemia vera begins with a history and physical examination.

Physical findings in someone with polycythemia vera may include:

• Enlarged spleen
• Enlarged liver
• Skin redness:
• Mainly in the face and extremities
• Bone tenderness

Tests are necessary to make the diagnosis of polycythemia vera.

Tests that may be used to evaluate polycythemia vera include:

• Bone marrow biopsy
• Complete blood count
• Histamine level
• Leukocyte alkaline phosphatase
• Uric acid level
• Vitamin B12 level