Stephen J. Schueler, M.D.

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Paget's Disease Underlying Cause

The exact cause of Paget's disease is unknown.

Bones are constantly changing. Old bone is removed by specialized bone cells, called osteoclasts, and new bone is laid down in its place by specialized cells, called osteoblasts. This process is known as bone remodeling. During childhood and adolescence the body is producing new bone faster than it is removing old bone. As a result, the skeletal system grows and becomes stronger. This usually reaches a peak between the age of 20 and 30.

Person's with Paget's have abnormal bone remodeling, which results in deformities of the bones. The pelvis, lumbar spine, femur, thoracic spine, sacrum, skull, tibia, and humerus are the most commonly affected bones.

Continue to Paget's Disease Anatomy

Last Updated: Oct 3, 2008 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Paget's Disease References
  1. Devogelaer JP. Modern therapy for Paget's disease of bone: focus on bisphosphonates. Treat Endocrinol. 2002;1(4):241-57. [15799218]
  2. Holgado S, Rotes D, Guma M, Monfort J, Olive A, Carbonell J, Tena X. Paget's disease of bone in early adult life. Ann Rheum Dis. 2005 Feb;64(2):306-8. [15647439]
  3. Langston AL, Ralston SH. Management of Paget's disease of bone. Rheumatology (Oxford). 2004 Aug;43(8):955-9. [15187244]
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