Paget's Disease of the Bone Anatomy
To better understand Paget's disease, it helps to understand the anatomy of the bony skeleton.
The skeleton is a living structure that supports the entire body. Bone is made up of an outer shell of very dense bone that surrounds a honeycomb-like structure of softer bone. Bone mainly consists of protein and calcium. Without calcium, bone will become weak.
The human skeleton can be divided into two sections:
- Axial skeleton:
- A total of 80 bones including the skull, spine, and chest
- Appendicular skeleton:
- A total of 126 bones including the pelvic girdle, limbs, feet and hands
- Devogelaer JP. Modern therapy for Paget's disease of bone: focus on bisphosphonates. Treat Endocrinol. 2002;1(4):241-57. 
- Holgado S, Rotes D, Guma M, Monfort J, Olive A, Carbonell J, Tena X. Paget's disease of bone in early adult life. Ann Rheum Dis. 2005 Feb;64(2):306-8. 
- Langston AL, Ralston SH. Management of Paget's disease of bone. Rheumatology (Oxford). 2004 Aug;43(8):955-9.