Complications of osteosarcoma include:

• Amputation
• Osteomyelitis
• Pathological fracture
• Side effects from chemotherapy
• Side effects from radiation therapy

Side effects of chemotherapy may include:

• Anorexia
• Bone marrow damage:
• Anemia
• Low platelet count
• Low white blood cell counts
• Constipation and diarrhea
• Excessive bruising
• Excessive bleeding
• Hair loss
• Heart failure
• Increased risk of infection
• Mouth sores (mucositis)
• Nausea and vomiting
• Weakness or fatigue
• Weight loss

Side effects of radiation therapy may include:

• Fatigue
• Hair loss
• Infertility
• Nausea and vomiting
• Other cancers
• Rashes
• Retarded bone growth in children
• Weight loss