Stephen J. Schueler, M.D.

Non-Hodgkin Lymphoma Staging

In order to determine the best treatment for non-hodgkin lymphoma, doctors need to know the stage of the lymphoma.

In order to stage lymphoma, two variables are determined:

  • The type of cells that are multiplying in the lymph nodes
  • Whether the lymphoma has spread to other lymph nodes or other organs

Most people with lymphoma are staged using the Ann Arbor system. This includes stages 1-4 (I-IV), along with certain letters that represent other factors.

The letter system includes:
  • A: no symptoms
  • B: symptoms of fever, night sweats or weight loss
  • E: spread to one site nearby, but outside of affected lymph nodes
  • X: bulky disease larger than 10 cm

Stage 1
In stage 1 (I), the lymphoma is present only in a single site, such as a lymph node.
Stage 2
In stage 2 (II), the lymphoma is present in 2 or more lymph nodes on the same side of the diaphragm, or in a single organ outside of the lymph nodes.
Stage 3
In stage 3 (III), the lymphoma is present on both sides of the diaphragm, with or without involvement of the spleen or other organs.
Stage 4
In stage 4 (IV), the lymphoma is present in multiple organs.

Continue to Non-Hodgkin Lymphoma Stage 1

Last Updated: Sep 21, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Non-Hodgkin Lymphoma References
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