Stephen J. Schueler, M.D.

Overview Symptoms

NMS Overview

Another name for NMS is Malignant Neuroleptic Syndrome.

What is malignant neuroleptic syndrome?
A person with malignant neuroleptic syndrome has a rare but serious reaction to a neuroleptic medication. Neuroleptic medications include the antipsychotic medications often used to treat schizophrenia and other psychotic disorders.

What are the symptoms of malignant neuroleptic syndrome?
Symptoms that may develop include rapid pulse, low blood pressure, hypertension, changes in mental status, excessive sleepiness (lethargy), confusion, coma, excessive sweating, rapid breathing, tremor, muscle rigidity, urinary incontinence, and fever.

How does the doctor treat malignant neuroleptic syndrome?
Treatment for this condition is an emergency. Treatment is directed at supportive care and stopping the antipsychotic medication that may be triggering the condition. Supportive care includes intravenous fluids, medications to control fever, and cooling blankets.

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