Neuropathic Arthritis Underlying Cause
A person with peripheral neuropathy has damage to the nerves that carry information between the body and the spinal cord. Nerve damage causes decreased sensation around a joint and changes the blood flow to the joint. These changes result in breakdown of the tissues inside the joint. In turn, the joint becomes damaged and inflamed. Charcot joint is caused by this destructive process.
Any condition that causes a peripheral neuropathy may cause Charcot joint.
Conditions that may be associated with Charcot joint include:
- Aliabadi P, Nikpoor N, Alparslan L. Imaging of neuropathic arthropathy. Semin Musculoskelet Radiol. 2003 Sep;7(3):217-25. 
- Armstrong DG, Peters EJ. Charcot's arthropathy of the foot. J Am Podiatr Med Assoc. 2002 Jul-Aug;92(7):390-4. 
- Trepman E, Nihal A, Pinzur MS. Current topics review: Charcot neuroarthropathy of the foot and ankle. Foot Ankle Int. 2005 Jan;26(1):46-63.