Stephen J. Schueler, M.D.

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Nephrotic Syndrome Overview

What is nephrotic syndrome?
A person with nephrotic syndrome has kidney disease that causes increased protein in the urine and low levels of protein in the bloodstream, as well as high cholesterol levels. Nephrotic syndrome can be caused by illness that damage the kidneys. About 3 out of 100,000 adults in the US develop nephrotic syndrome each year.

What are the symptoms of nephrotic syndrome?
Symptoms of nephrotic syndrome include facial swelling, leg swelling, foot swelling, arm swelling, abdominal swelling, scrotal swelling, decreased urination, numbness and tingling, anorexia, pale skin, excessive bruising, and weight gain. Symptoms of severe nephrotic syndrome include shortness of breath and confusion.

How does the doctor treat nephrotic syndrome?
Treatment for nephrotic syndrome may include kidney disease diet, corticosteroids, ACE inhibitors, diuretics, fluid restriction, vitamin supplements, and sodium restriction. Additional treatment may include kidney dialysis or peritoneal dialysis.

Continue to Nephrotic Syndrome Incidence

Last Updated: Oct 25, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Nephrotic Syndrome References
  1. Durkan A, Hodson EM, Willis NS, Craig JC. Non-corticosteroid treatment for nephrotic syndrome in children. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD002290. [15846634]
  2. Habashy D, Hodson EM, Craig JC. Interventions for steroid-resistant nephrotic syndrome: a systematic review. Pediatr Nephrol. 2003 Sep;18(9):906-12. [12836096]
  3. Hodson EM, Knight JF, Willis NS, Craig JC. Corticosteroid therapy for nephrotic syndrome in children. Cochrane Database Syst Rev. 2005 Jan 25;(1):CD001533. [15674881]
  4. Hogg RJ. Adolescents with proteinuria and/or the nephrotic syndrome. Adolesc Med Clin. 2005 Feb;16(1):163-72. [15844389]
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