Stephen J. Schueler, M.D.

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Nephroblastoma Overview

Another name for Nephroblastoma is Wilms Tumor.

What is Wilm's tumor?
A child with Wilm's tumor has abnormal cells in the kidney that multiply out of control. These cells can form tumors and spread to other parts of the body. The cause of Wilm's tumor is unknown, but genetics may play a role in determining risk. About 1 out of 200,000 children in the US develop Wilm's tumor each year. Wilm's tumor is most common in children who are 3 years old.

What are the symptoms of Wilm's tumor?
Symptoms of Wilm's tumor include abdominal pain, abdominal swelling, loss of appetite, constipation, and blood in the urine.

How does the doctor treat Wilm's tumor?
Treatment for Wilm's tumor may include surgery, chemotherapy, or radiation therapy.

Continue to Nephroblastoma Incidence

Last Updated: Aug 31, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Nephroblastoma References
  1. Blakely ML, Shamberger RC, et al; National Wilms' Tumor Study Group. Outcome of children with cystic partially differentiated nephroblastoma treated with or without chemotherapy. J Pediatr Surg. 2003 Jun;38(6):897-900. [12778388]
  2. Kremens B, Gruhn B, Klingebiel T, et al. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. Bone Marrow Transplant. 2002 Dec;30(12):893-8. [12476282]
  3. McLorie GA. Wilms' tumor (nephroblastoma). Curr Opin Urol. 2001 Nov;11(6):567-70. [11734691]
  4. Pritchard-Jones K, Kelsey A, et al; United Kingdom Children's Cancer Study Group; Wilm's Tumor Working Group. Older age is an adverse prognostic factor in stage I, favorable histology Wilms' tumor treated with vincristine monochemotherapy: a study by the United Kingdom Children's Cancer Study Group, Wilm's Tumor Working Group. J Clin Oncol. 2003 Sep 1;21(17):3269-75. [12947062]
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