Stephen J. Schueler, M.D.

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Multiple Myeloma Underlying Cause

Individuals with multiple myeloma have an abnormal elevation in the number of plasma cells in the bone marrow and blood. This can lead to an erosion of the bone tissue and kidney damage.

The cause of multiple myeloma is unknown, but genetics may play a role in determining risk. Certain genes may provide increased susceptibility to multiple myeloma. Toxic exposure to certain chemicals and radiation may trigger the onset of multiple myeloma.


  • DNA
  • Genes on chromosomes
  • Cancer cells
  • Cancer cell division

Continue to Multiple Myeloma Anatomy

Last Updated: Apr 22, 2009 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Multiple Myeloma References
  1. Angtuaco EJ, Fassas AB, Walker R, Sethi R, Barlogie B. Multiple myeloma: clinical review and diagnostic imaging. Radiology. 2004 Apr;231(1):11-23. [14990813]
  2. Kumar A, Loughran T, Alsina M, Durie BG, Djulbegovic B. Management of multiple myeloma: a systematic review and critical appraisal of published studies. Lancet Oncol. 2003 May;4(5):293-304. [12732167]
  3. Lynch HT, Sanger WG, Pirruccello S, Quinn-Laquer B, Weisenburger DD. Familial multiple myeloma: a family study and review of the literature. J Natl Cancer Inst. 2001 Oct 3;93(19):1479-83. [11584064]
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