The evaluation of mononucleosis begins with a medical history and physical exam.

Physical findings in someone with mononucleosis may include:

• Tonsillitis:
• Red, swollen tonsils
• Red throat
• Rash
• Swollen glands in the neck
• Spleen enlargement
• Right upper abdominal pain:
• Mild tenderness over the liver
• Jaundice:
• Yellow skin
• Yellow eyes
• Brown urine
• Eye redness:
• Viral conjunctivitis

Tests that may be used to evaluate mononucleosis include:

• Monospot
• Complete blood count
• Epstein-Barr virus testing
• Throat culture
• Liver profile