There is no cure for mononucleosis. Treatment for mononucleosis usually includes rest, oral fluids, sore throat sprays and lozenges, warm saltwater gargles, and acetaminophen or nonsteroidal anti-inflammatory medications for pain and fever. Those who have severe throat swelling may require treatment with corticosteroids.
Treatment options for those with mononucleosis include:
- Drink plenty of liquids.
- Take nonprescription medication for sore throat:
- Gargle with warm salt water
- Avoid contact sports and heavy lifting until symptoms resolve:
- Risk of injury to the spleen due to spleen swelling
- Acetaminophen for pain and fever control
- Nonsteroidal anti-inflammatory medications for pain and fever control:
- Ibuprofen (Motrin, Advil, Nuprin, NeoProfen)
- Ketoprofen (Actron, Orudis, Oruvail)
- Naproxen (Anaprox, Naprosyn, Aleve)
- Oral corticosteroids for mononucleosis:
- Prednisone (Deltasone, Orasone, Sterapred)
- For severe throat swelling
- For those with the potential for airway swelling
- For those with autoimmune hemolytic anemia
- For those with severe thrombocytopenia
- For those with evidence of cardiac involvement, such as pericarditis or myocarditis
- For those with evidence of neurological involvement, such as Guillain-Barre syndrome
Mono Questions For Doctor
The following are some important questions to ask before and after treatment for mononucleosis.
Questions to ask before treatment:
- What are my treatment options?
- What are the risks associated with treatment?
- Am I contagious?
- For how long?
- What are the complications I should watch for?
- How long will I be on medication?
- What are the potential side effects of my medication?
- Does my medication interact with nonprescription medicines or supplements?
- Should I take my medication with food?
Questions to ask after treatment:
- Do I need to change my diet?
- Are there any medications or supplements I should avoid?
- When can I resume my normal activities?
- When can I return to work?
- What else can I do to reduce my risk for complications?
- How do I avoid passing the infection to others?
- How often will I need to see my doctor for checkups?
- What local support and other resources are available?
Physicians from the following specialties evaluate and treat mononucleosis:
Continue to Mono Home Care
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- Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Physician. 2004 Oct 1;70(7):1279-87. 
- Grotto I, Mimouni D, Huerta M, Mimouni M, Cohen D, Robin G, Pitlik S, Green MS. Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults. Epidemiol Infect. 2003 Aug;131(1):683-9. 
- Hanna BC, McMullan R, Hall SJ. Corticosteroids and peritonsillar abscess formation in infectious mononucleosis. J Laryngol Otol. 2004 Jun;118(6):459-61. 
- Kinderknecht JJ. Infectious mononucleosis and the spleen. Curr Sports Med Rep. 2002 Apr;1(2):116-20.