The evaluation of mesothelioma begins with a history and physical exam. Physical exam is usually normal.

Physical findings in someone with mesothelioma may include:

• Clubbing of the nails
• Barrel-shaped chest
• Decreased lung sounds
• During examination with a stethoscope
• Malnutrition
• Wheezing

Testing is necessary to make the diagnosis of mesothelioma.

Tests that may be used to evaluate mesothelioma include:

• Pulse oximetry
• Complete blood count
• Kidney profile
• Serum electrolytes
• Pulse oximetry
• Chest x-ray
• Bronchoscopy
• Sputum cytology:
• Tests lung mucus cells for cancer
• Blood telomerase
• CT scan of the chest
• MRI scan of the chest
• Bone scan
• Mediastinoscopy:
• A small fiber optic scope is introduced through a tiny incision in the chest wall.
• Thoracoscopy:
• A small fiber optic scope is introduced through a tiny incision in the chest wall.
• PET scan