Stephen J. Schueler, M.D.

Medulloblastoma Anatomy

To better understand medulloblastoma, it helps to understand the anatomy of the brain.

Doctors often refer to the location of a brain tumor as being either infratentorial or supratentorial. Infratentorial tumors are located in the lower, back one-third of the brain. Supratentorial tumors arise within the front two-thirds of the brain.

Brain Anatomy
The brain is well protected by:

  • The scalp
  • The skull
  • The dura
    • A tough 3-layer sheath that surrounds the brain and spinal cord
    • Layers include the dura mater (strongest layer), arachnoid mater (middle layer), and pia mater (closest to the brain)

The brain is a complicated structure containing many parts. These include:
  • The cerebrum:
    • Made up of two cerebral hemispheres that are connected in the middle
    • It is the largest part of the brain
    • Each area of the cerebrum performs an important function, such as language or movement
    • Higher thought (cognition) comes from the frontal cortex (front portion of the cerebrum)
    • Outside of the cerebrum are blood vessels
    • There are fluid-filled cavities and channels inside the brain
  • The cerebellum:
    • Located in the lower, back part of the skull
    • Controls movement and coordination
  • The brainstem and pituitary gland:
    • Responsible for involuntary functions such as breathing, body temperature, and blood pressure regulation
    • Pituitary gland is the "master gland" that controls other endocrine glands in the body, such as the thyroid and adrenal glands
  • The cranial nerves:
    • Twelve large nerves exit the bottom of the brain to supply function to the senses such as hearing, vision, and taste
  • The cerebral blood vessels:
    • A complicated system that supplies oxygenated blood and nutrients to the brain

The blood supply to the brain is divided into two main parts:
  • Anterior cerebral circulation:
    • The front of the brain is supplied by the paired carotid arteries in the neck.
  • Posterior cerebral circulation:
    • The back portion of the brain is supplied by the paired vertebral arteries in the spine.

Anatomy examples:
  • Carotid artery branches shown on arteriogram
  • Cerebral arteries viewed in cross-section through middle of brain
  • Cerebral arteries viewed from bottom of brain
  • Cerebral arteries on enhanced CT scan
  • Cerebral arteries on arteriogram

Last Updated: Dec 22, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Medulloblastoma References
  1. Brandes AA, Paris MK. Review of the prognostic factors in medulloblastoma of children and adults. Crit Rev Oncol Hematol. 2004 May;50(2):121-8. [15157661]
  2. Calaminus G, Janssen G, Lenard HG, Bock WJ, Reifenberger G, Schmitt G, Gobel U. Combined therapy of medulloblastoma: review of 46 patients treated in a single institution. Neuropediatrics. 1998 Apr;29(2):102-7. [9638665]
  3. Salvati M, Cervoni L. Medulloblastoma in late adults. Case report and critical review of the literature. J Neurosurg Sci. 2000 Dec;44(4):230-2; discussion 232-3. [11327293]
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