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Lymphoma Non-Hodgkin Staging
- The type of cells that are multiplying in the lymph nodes
- Whether the lymphoma has spread to other lymph nodes or other organs
Most people with lymphoma are staged using the Ann Arbor system. This includes stages 1-4 (I-IV), along with certain letters that represent other factors.
The letter system includes:
- A: no symptoms
- B: symptoms of fever, night sweats or weight loss
- E: spread to one site nearby, but outside of affected lymph nodes
- X: bulky disease larger than 10 cm
In stage 1 (I), the lymphoma is present only in a single site, such as a lymph node.
In stage 2 (II), the lymphoma is present in 2 or more lymph nodes on the same side of the diaphragm, or in a single organ outside of the lymph nodes.
In stage 3 (III), the lymphoma is present on both sides of the diaphragm, with or without involvement of the spleen or other organs.
In stage 4 (IV), the lymphoma is present in multiple organs.
Continue to Lymphoma Non-Hodgkin Stage 1
PubMed Lymphoma Non-Hodgkin References
- Klencke B, Kaplan L. Advances and future challenges in non-Hodgkin's lymphoma. Curr Opin Oncol. 1998 Sep;10(5):422-7. 
- Kouroukis CT, Browman GP, Esmail R, Meyer RM. Chemotherapy for older patients with newly diagnosed, advanced-stage, aggressive-histology non-Hodgkin lymphoma: a systematic review. Ann Intern Med. 2002 Jan 15;136(2):144-52. 
- Lamm SH, Engel A, Byrd DM. Non-Hodgkin lymphoma and benzene exposure: a systematic literature review. Chem Biol Interact. 2005 May 30;153-154:231-7. 
- Martin-Duverneuil N, Mokhtari K, Behin A, Lafitte F, Hoang-Xuan K, Chiras J. Intravascular malignant lymphomatosis. Neuroradiology. 2002 Sep;44(9):749-54.