Stephen J. Schueler, M.D.

Lymphocytic Leukemia Chronic Bone Marrow Transplant

Some patients with chronic lymphocytic leukemia may benefit from high-dose chemotherapy, followed by infusion of immature stem cells back into the bone marrow. This is called a bone marrow transplant, or stem cell transplant.

There are 3 main types of bone marrow transplantation that can be performed:

Autologous Bone Marrow Transplant
This method involves using the person's own bone marrow. Before the transplant and during remission, doctors will remove some of the bone marrow, and treat it with drugs to kill cancer cells. Normal marrow cells will be saved and frozen. After chemotherapy or radiation therapy the cancer-free bone marrow will be given back by IV infusion.

Syngeneic Transplant
This involves donated marrow from an identical twin. It is ideal when the donor is available. In genetically identical twins, the body does not reject the transplanted marrow, nor does the marrow reject the body.

Allogeneic Transplant
The donor is usually a parent, sibling or other person whose marrow type closely matches that of the patient. Using a large marrow database a donor can be found that is a close bone marrow match.

Close matching reduces the possibility of transplant rejection. Rejection occurs in 30% to 50% of bone marrow transplants.

Continue to Lymphocytic Leukemia Chronic Chemotherapy

Last Updated: Jun 2, 2011 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Lymphocytic Leukemia Chronic References
  1. Yee KW, O'Brien SM. Chronic lymphocytic leukemia: diagnosis and treatment. Mayo Clin Proc. 2006 Aug;81(8):1105-29. [16901035]
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