The evaluation of Lyme disease begins with a history and physical exam.

Physical findings in someone with Lyme disease may include:

• Bell's palsy:
• Weakness of the face on one side
• Fever
• Irregular heartbeat
• Joint swelling
• Numbness
• Red, circular rash:
• Looks like a bull's eye target
• May appear as a spreading red rash
• Usually fades within ten days
• Stiff neck
• Swollen glands
• Weakness or fatigue
• Mild confusion

Tests that may be used to evaluate Lyme disease include:

• Enzyme-Linked Immunosorbent Assay (ELISA)
• Indirect Fluorescent Antibody (IFA)
• Western Blot
• Polymerase Chain Reaction (PCR)