Low Alkaline Phosphatase Types
Types of hypophosphatasia include:
- Infantile hypophosphatasia:
- The most common and severe form
- Childhood hypophosphatasia:
- A less severe form
- Adult Hypophosphatasia:
- Very rare form that is not detected until later in life
Low Alkaline Phosphatase Adult
Adult hypophosphatasia is very rare and shares many of the same features as childhood hypophosphatasia.
Symptoms of hypophosphatasia in adults include:
Low Alkaline Phosphatase Childhood
Symptoms of childhood hypophosphatasia start after 6 months of age.
Symptoms of hypophosphatasia in children include:
- Retarded growth
- Premature loss of primary teeth
- Loss of bone density
- Bony deformities
- Bone fractures
Low Alkaline Phosphatase Infantile
Infantile hypophosphatasia is the most common form of hypophosphatasia. Symptoms start before 6 months of age.
Symptoms of hypophosphatasia in infants include:
- Bone deformities
- Failure to thrive
- Poor feeding in infants
- Poor weight gain
- Poor growth
- High blood calcium levels (hypercalcemia)
- Kidney stones
Less than 50% of infants survive the illness.
- Girschick HJ, Schneider P, Kruse K, Huppertz HI. Bone metabolism and bone mineral density in childhood hypophosphatasia. Bone. 1999 Sep;25(3):361-7. 
- Girschick HJ, Seyberth HW, Huppertz HI. Treatment of childhood hypophosphatasia with nonsteroidal antiinflammatory drugs. Bone. 1999 Nov;25(5):603-7. 
- Wendling D, Jeannin-Louys L, Kremer P, Fellmann F, Toussirot E, Mornet E. Adult hypophosphatasia. Current aspects. Joint Bone Spine. 2001 Mar;68(2):120-4.