The evaluation of Leishmaniasis begins with a history and physical examination.

Physical findings in someone with Leishmaniasis may include:

• Swollen lymph nodes
• Enlarged liver
• Enlarged spleen
• Skin rash
• Skin ulcers

Testing is required to confirm the diagnosis of Leishmaniasis.

Tests that may be used to evaluate Leishmaniasis include:

• Complete blood count
• Serum ELISA testing
• Skin test for cutaneous Leishmaniasis
• Serum albumin levels:
• May be low
• Tissue biopsy from an affected area:
• Lymph node biopsy
• Liver biopsy
• Bone marrow biopsy
• Spleen biopsy