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Underlying Cause
Leg Numbness due to Diabetes Evaluation
The evaluation of diabetic neuropathy starts with a history and physical examination. ![]()
Physical findings in someone with diabetic nephropathy may include:
- Skin breakdown or ulcers:
- Weak pulse in the ankles and feet


- Skin changes due to peripheral vascular disease

- Decreased sensation in the feet and legs
Testing may be necessary to assess the severity of the diabetic neuropathy.
Tests that may be used to evaluate diabetic neuropathy include:
- Complete blood count

- Glycosylated hemoglobin (hemoglobin A1c)

- Vitamin B12 level

- Folic acid level

- Drug screen

- VDRL:
- Blood test that screens for syphilis

- Electromyogram

- Nerve biopsy
- Nerve conduction studies

Less common tests that may be used to evaluate diabetic neuropathy include:
- Lumbar puncture with spinal fluid analysis

- CT scanning of the brain

- MRI scan of the brain


For more information:
Continue to Leg Numbness due to Diabetes Treatment
Last Updated: Dec 9, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Leg Numbness due to Diabetes References
- Corbett CF. Practical management of patients with painful diabetic neuropathy. Diabetes Educ. 2005 Jul-Aug;31(4):523-4, 526-8. [16100329]
- Malik RA. Current and future strategies for the management of diabetic neuropathy. Treat Endocrinol. 2003;2(6):389-400. [15981943]
- Olson DE, Norris SL. Diabetes in older adults. Overview of AGS guidelines for the treatment of diabetes mellitus in geriatric populations. Geriatrics. 2004 Apr;59(4):18-24. [15086070]
- Sullivan KA, Feldman EL. New developments in diabetic neuropathy. Curr Opin Neurol. 2005 Oct;18(5):586-90. [16155445]