Stephen J. Schueler, M.D.

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Knee Chondromalacia Drugs

Drug treatment usually starts with acetaminophen, which is adequate for many people. Acetaminophen suppresses the body's production of the chemicals that cause pain, but does not reduce inflammation. Most people with moderate pain eventually require a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen or naproxen. NSAIDS reduce pain and swelling by blocking the body's production of chemicals that cause pain and inflammation.

Hyaluronan Injections
This treatment is approved for osteoarthritis but may provide temporary relief for those with pain in the knee joints from chondromalacia as well. Hyaluronic acid is a natural component of joint fluid. It acts as a lubricant and shock absorber inside the joints. Inflammation causes the acid to break down, decreasing its effectiveness. Hyaluronan (e.g. Hyalgan and Synvisc) is a synthetic version of the substance that can be administered directly into the joint, usually a series of three shots given over one week.

Hyaluronan not a permanent solution, but pain relief can last for months. It is especially helpful for people who can't take steady high doses of nonsteroidal anti-inflammatory agents or those who fail to respond to other medications.

Continue to Knee Chondromalacia Exercises

Last Updated: May 31, 2011 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Knee Chondromalacia References
  1. Bosch JJ. Chondromalacia patella. J Pediatr Health Care. 1999 May-Jun;13(3 Pt 1):144. [10531909]
  2. Fredericson M, Yoon K. Physical examination and patellofemoral pain syndrome. Am J Phys Med Rehabil. 2006 Mar;85(3):234-43. [16505640]
  3. Holmes SW Jr, Clancy WG Jr. Clinical classification of patellofemoral pain and dysfunction. J Orthop Sports Phys Ther. 1998 Nov;28(5):299-306. [9809278]
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