Keratosis Nigricans Treatment
The treatment for acanthosis nigricans may depend on the underlying cause. General therapy includes losing weight if you are overweight, a diet low in starch and sugar, and stopping medications that cause acanthosis nigricans as a side effect. Hereditary forms of this acanthosis may not respond to treatment. In order to reduce the severity of the skin lesions, treatment may also include topical or oral medications, laser therapy, or surgery. In most cases, long-term therapy is required.
Options to treat acanthosis nigricans include:
- Weight loss for those who are overweight
- Change in diet:
- Reduce starch in the diet.
- Reduce sugar in the diet
- Fish oil supplements (omega-3 fatty acids):
- Stop medication if acanthosis is due to a drug side effect.
- Topical medications:
- Oral medication:
- Surgery, if related to a primary tumor.
- Laser surgery to improve appearance
- Using a special device, the surgeon removes the outermost layer of the skin.
Keratosis Nigricans Specialist
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- Matsuoka LY, Wortsman J, Gavin JR, Goldman J. Spectrum of endocrine abnormalities associated with acanthosis nigricans. Am J Med. 1987 Oct;83(4):719-25. 
- Olson KK. Acanthosis nigricans. A guide to assessment and evaluation. Adv Nurse Pract. 2004 Dec;12(12):24-6.