Stephen J. Schueler, M.D.

Ischemic Cardiomyopathy Underlying Cause

Ischemic cardiomyopathy is caused by a reduced supply of oxygen to the heart. The coronary arteries deliver blood and oxygen to the heart. Coronary artery disease is the most common cause for ischemic cardiomyopathy.

The coronary arteries become blocked by a process known as atherosclerosis, which is also called hardening of the arteries.

The process of atherosclerosis includes:

  • The inner wall of the artery becomes damaged by changes in blood flow, infection, smoking, diabetes, or high blood pressure.
  • As the wall or the artery attempts to repair itself, cholesterol builds up on the inside surface of the artery, forming a plaque.
  • Plaques narrow the inside of the arteries, which reduces blood flow.

Additional conditions that are caused by coronary artery disease include:

Continue to Ischemic Cardiomyopathy Anatomy

Last Updated: May 21, 2008 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Ischemic Cardiomyopathy References
  1. Morrison DA. What is the evidence for percutaneous coronary intervention or coronary artery bypass graft in ischemic cardiomyopathy? Am Heart Hosp J. 2005 Summer;3(3):175-81. [16106138]
  2. Moustakidis P, Cupps BP, Pomerantz BJ, Scheri RP, Maniar HS, Kates AM, Gropler RJ, Pasque MK, Sundt TM. Noninvasive, quantitative assessment of left ventricular function in ischemic cardiomyopathy. J Surg Res. 2004 Feb;116(2):187-96. [15013355]
  3. O'Connor CM, Velazquez EJ, Gardner LH, Smith PK, Newman MF, Landolfo KP, Lee KL, Califf RM, Jones RH. Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank). Am J Cardiol. 2002 Jul 15;90(2):101-7. [12106836]
  4. Yao SS, Qureshi E, Nichols K, Diamond GA, Depuey EG, Rozanski A. Prospective validation of a quantitative method for differentiating ischemic versus nonischemic cardiomyopathy by technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. Clin Cardiol. 2004 Nov;27(11):615-20. [15562931]
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