Stephen J. Schueler, M.D.

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Hypogammaglobulinemia Treatment

Because a person with agammaglobulinemia is missing antibodies, treatment includes replacing the antibodies, called immunoglobulins, in the bloodstream. Antibodies are given through an intravenous (IV) line every 3 to 4 weeks. Because agammaglobulinemia weakens the immune system, bacterial infections require early and aggressive treatment with antibiotics. A person with agammaglobulinemia should not receive live vaccines for common viral infections, such as measles, mumps and rubella, because they may cause infection.

Specific treatment for agammaglobulinemia may include:

  • Intravenous immune globulin (IVIG) therapy for agammaglobulinemia:
    • Helps boost the immune system, by replacing lost antibodies
  • Antibiotic therapy for infections:
    • Early treatment is very important, in order to avoid severe infections.

Hypogammaglobulinemia Specialist

Physicians from the following specialties evaluate and treat agammaglobulinemia:

Continue to Hypogammaglobulinemia Complications

Last Updated: Jun 3, 2011 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Hypogammaglobulinemia References
  1. Buckley RH: Pulmonary complications of primary immunodeficiencies. Paediatr Respir Rev 2004; 5 (Suppl A): S225-33. [14980276]
  2. Conley ME: Early defects in B cell development. Curr Opin Allergy Clin Immunol 2002; 2: 517-22. [14752335]
  3. Dalal I, Reid B, Nisbet-Brown E, Roifman CM: The outcome of patients with hypogammaglobulinemia in infancy and early childhood. J Pediatr 1998 Jul; 133(1): 144-6. [9672529]
  4. Kidon MI, Handzel ZT, Schwartz R et al.: Symptomatic hypogammaglobulinemia in infancy and childhood: clinical outcome and in vitro immune responses. BMC Fam Pract 2004; 5: 23. [15498106]
  5. Lawrence T, Puel A, Reichenbach J, Ku CL, Chapgier A, Renner E, Minard-Colin V, Ouachee M, Casanova JL. Autosomal-dominant primary immunodeficiencies. Curr Opin Hematol. 2005 Jan;12(1):22-30. [15604887]
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