Stephen J. Schueler, M.D.

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Hypogammaglobulinemia Overview

Another name for Hypogammaglobulinemia is Agammaglobulinemia.

What is agammaglobulinemia?
In a person with agammaglobulinemia, the body does not make enough B-lymphocytes. B-lymphocytes are white blood cells that produce immune globulins, which protect the body from infection. Without these immune globulins, a person suffers from repeated infections.

What are the symptoms of agammaglobulinemia?
Common symptoms of agammaglobulinemia include fever, repeated bacterial infections, joint pains, and unintentional weight loss.

How does the doctor treat agammaglobulinemia?
Treatment for agammaglobulinemia includes antibiotics for bacterial infections, and the administration of immune globulin to boost the immune system.

Continue to Hypogammaglobulinemia Incidence

Last Updated: Feb 5, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Hypogammaglobulinemia References
  1. Buckley RH: Pulmonary complications of primary immunodeficiencies. Paediatr Respir Rev 2004; 5 (Suppl A): S225-33. [14980276]
  2. Conley ME: Early defects in B cell development. Curr Opin Allergy Clin Immunol 2002; 2: 517-22. [14752335]
  3. Dalal I, Reid B, Nisbet-Brown E, Roifman CM: The outcome of patients with hypogammaglobulinemia in infancy and early childhood. J Pediatr 1998 Jul; 133(1): 144-6. [9672529]
  4. Kidon MI, Handzel ZT, Schwartz R et al.: Symptomatic hypogammaglobulinemia in infancy and childhood: clinical outcome and in vitro immune responses. BMC Fam Pract 2004; 5: 23. [15498106]
  5. Lawrence T, Puel A, Reichenbach J, Ku CL, Chapgier A, Renner E, Minard-Colin V, Ouachee M, Casanova JL. Autosomal-dominant primary immunodeficiencies. Curr Opin Hematol. 2005 Jan;12(1):22-30. [15604887]
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