Stephen J. Schueler, M.D.

Hodgkin's Disease Staging

In order to determine the best treatment, doctors need to know the stage of the lymphoma.

In order to stage lymphoma, two variables are determined:

  • The type of cells that are multiplying in the lymph nodes
  • Whether the lymphoma has spread to other lymph nodes or other organs

Most people with lymphoma are staged using the Ann Arbor system. This includes stages 1-4 (I-IV), along with certain letters that represent other factors.

The letter system includes:
  • A: no symptoms
  • B: symptoms of fever, night sweats or weight loss
  • E:spread to one site nearby, but outside of affected lymph nodes
  • X: bulky disease larger than 10 cm

Stage 1
In stage 1 (I), the lymphoma is present only in a single site, such as a lymph node.
Stage 2
In stage 2 (II), the lymphoma is present in 2 or more lymph nodes on the same side of the diaphragm, or in a single organ outside of the lymph nodes.
Stage 3
In stage 3 (III), the lymphoma is present on both sides of the diaphragm, with or without involvement of the spleen or other organs.
Stage 4
In stage 4 (IV), the lymphoma is present in multiple organs.

Continue to Hodgkin's Disease Stage 1

Last Updated: Nov 7, 2008 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Hodgkin's Disease References
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  2. Dieckmann K, Potter R, Wagner W, Prott FJ, Hornig-Franz I, Rath B, Schellong G. Up-front centralized data review and individualized treatment proposals in a multicenter pediatric Hodgkin's disease trial with 71 participating hospitals: the experience of the German-Austrian pediatric multicenter trial DAL-HD-90. Radiother Oncol. 2002 Feb;62(2):191-200. [11937246]
  3. McCunney RJ. Hodgkin's disease, work, and the environment. A review. J Occup Environ Med. 1999 Jan;41(1):36-46. [9924719]
  4. Provencio M, Espana P, Millan I, Yebra M, Sanchez AC, de la Torre A, Bonilla F, Regueiro CA, de Letona JM. Prognostic factors in Hodgkin's disease. Leuk Lymphoma. 2004 Jun;45(6):1133-9. [15359992]
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