Most histoplasmosis infections occur in those with a poorly functioning immune system. No treatment is required for patients with a normally functioning immune system and no symptoms.
Treatment for histoplasmosis may include antifungal medications, and acetaminophen or nonsteroidal anti-inflammatory medications for pain and fever. About 99% of patients with histoplasmosis improve without treatment.
Treatment options for histoplasmosis include:
- Anti-fungal medications for histoplasmosis:
- Nonsteroidal anti-inflammatory medications for pain:
- Ibuprofen (Motrin, Advil, Nuprin, NeoProfen)
- Ketoprofen (Actron, Orudis, Oruvail)
- Naproxen (Anaprox, Naprosyn, Aleve)
- May be prescribed to decrease a hypersensitivity response to histoplasmosis infection
- Prednisone (Sterapred)
- Histoplasmosis surgery:
- May be performed to obtain a tissue biopsy to confirm the infection
- May be employed to remove a cavitary lesion from the lungs
- May be performed to correct complications involving the heart (e.g. pericardial effusion)
- May be performed to correct eye infection
Histoplasmosis Questions For Doctor
The following are some important questions to ask before and after the treatment of histoplasmosis.
Questions to ask before treatment:
- What are my treatment options?
- What are the risks associated with treatment?
- Do I need to stay in the hospital?
- How long will I be in the hospital?
- Am I contagious?
- For how long?
- What are the complications I should watch for?
- How long will I be on medication?
- What are the potential side effects of my medication?
- Does my medication interact with nonprescription medicines or supplements?
- Should I take my medication with food?
Questions to ask after treatment:
- Do I need to change my diet?
- Are there any medications or supplements I should avoid?
- When can I resume my normal activities?
- When can I return to work?
- What else can I do to reduce my risk for complications?
- How do I avoid passing the infection to others?
- How often will I need to see my doctor for checkups?
- What local support and other resources are available?
Physicians from the following specialties evaluate and treat histoplasmosis:
Continue to Histoplasmosis Home Care
- Cano MV, Hajjeh RA. The epidemiology of histoplasmosis: a review. Semin Respir Infect. 2001 Jun;16(2):109-18. 
- Wheat J. Histoplasmosis. Experience during outbreaks in Indianapolis and review of the literature. Medicine (Baltimore). 1997 Sep;76(5):339-54.