The evaluation of histoplasmosis begins with a history and physical examination.

Physical findings in someone with histoplasmosis may include:

• Weight loss
• Enlargement of liver
• Enlargement of spleen
• Lymph node swelling:
• Swollen lymph glands in the neck
• Swollen glands in the groin
• Swollen glands under the arm
• Mouth or tongue lesions:
• Mouth ulcers
• Tongue ulcers
• Eye redness:
• Uveitis
• Tenderness over the liver
• Jaundice

Tests are necessary to make the diagnosis of histoplasmosis. A biopsy of infected tissue is necessary to confirm the diagnosis.

Tests that may be used to evaluate histoplasmosis include:

• Chest x-ray
• Complete blood count
• Lactic dehydrogenase: LDH
• Histoplasmosis antibody titer
• Lung biopsy
• Liver biopsy
• Bone marrow biopsy
• Bronchoscopy