Herpes gingivostomatitis usually resolves without treatment after 4 to 6 days. Medication may reduce symptoms or prevent episodes in those who have severe symptoms.

Treatment for herpes gingivostomatitis includes:

• Antiviral medications for herpes:
• Acyclovir (Zovirax)
• Penciclovir (Denavir)
• Famciclovir (Famvir)
• Nonsteroidal anti-inflammatory medications for pain
• Clean blisters on the skin thoroughly twice a day.
• Apply an antibiotic ointment.
• Clean blisters inside the mouth 3 times a day:
• Use hydrogen peroxide oral rinses.
• Soft diet
• Oral anesthetics:
• Anbesol
• Cepacol
• Chloraseptic
• Orajel