Stephen J. Schueler, M.D.

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Hereditary Spherocytosis Underlying Cause

Spherocytosis is an inherited disease. The red blood cell wall contains an abnormal protein, which changes the shape of red blood cells: the red blood cells are round, rather than elliptical. These deformed, round red blood cells have a shorter lifespan and tend to break down much faster in the bloodstream. This leads to a reduced number of red blood cells, called hemolytic anemia.

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Last Updated: Jun 19, 2009 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Hereditary Spherocytosis References
  1. Dhaliwal G, Cornett PA, Tierney LM Jr. Hemolytic anemia. Am Fam Physician. 2004 Jun 1;69(11):2599-606. [15202694]
  2. Perkins SL. Pediatric red cell disorders and pure red cell aplasia. Am J Clin Pathol. 2004 Dec;122 Suppl:S70-86. [15690644]
  3. Stoehr GA, Luecken J, Zielen S, Eber SW, Borrow R, Rose MA. Mode of splenectomy and immunogenicity of meningococcal vaccination in patients with hereditary spherocytosis. Br J Surg. 2008 Apr;95(4):466-71. [18161897]
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