The evaluation of hemolytic uremic syndrome starts with a medical history and physical examination.

Physical findings in someone with hemolytic uremic syndrome may include:

• A petechial skin rash
• Excessive skin bruising
• Pale skin
• Leg swelling (bilateral)
• Arm swelling (bilateral)

Tests are required to make the diagnosis of hemolytic uremic syndrome.

Tests that may be used to evaluate hemolytic uremic syndrome include:

• Serum fibrin split products level
• Serum haptoglobin
• Serum hemoglobin
• Kidney profile
• Liver profile
• Platelet count
• Red cell smear:
• Peripheral smear
• Reticulocyte count
• White blood cell count
• Urinalysis
• Stool cultures