Evaluation is of gynecomastia begins with a history and physical examination.

Physical findings in someone with gynecomastia may include:

• Breast enlargement is usually symmetric on both sides.
• Sometimes enlargement may be one-sided and mimic a breast mass.

Testing may be necessary to evaluate gynecomastia.

Tests that may be used to evaluate gynecomastia include:

• Human chorionic gonadotropin level (HCG)
• Liver function tests
• Plasma testosterone level
• Serum estrogen level
• Serum prolactin level
• Thyroid profile

Additional tests that may be used to evaluate gynecomastia include:

• Genetic testing may be necessary in some cases.
• MRI scan of the brain