Evaluation of Guillain-Barre syndrome is mainly based on a history and physical examination.

Physical findings in someone with Guillain-Barre syndrome may include:

• Decreased or absent reflexes
• Changes in blood pressure
• Changes in heart rate
• Hand numbness (bilateral)
• Arm numbness (bilateral)
• Leg numbness (bilateral)
• Arm weakness (bilateral)
• Leg weakness (bilateral)
• Hand weakness (bilateral)
• Facial weakness:
• Facial drooping
• Difficulty speaking:
• Slurred speech

Tests that may be used to evaluate Guillain-Barre syndrome include:

• Complete blood count
• Erythrocyte sedimentation rate
• Lumbar puncture
• Serum B12 level
• Serum folate level
• Hemoglobin A1C
• Serum protein electrophoresis
• Nerve conduction studies
• MRI scan of the brain
• EMG
• Pulmonary function tests